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A Study on Antidiabetic and Antioxidant Efficacy of Bone Marrow Stem Cells on STZE-Induced Male Albino Wistar Rats

C. Pihoker, C. Jefferies


Diabetes has become one of the most serious threats to public health worldwide, with an estimated 117 million cases in the world's population. Diabetes is a serious and complex chronic disease characterized by impaired metabolism of carbohydrates, proteins and fats due to hyperglycemia and an absolute or relative lack of the hormone insulin. Diabetes may be clinically suspected or recognized due to the onset of one or more characteristic symptoms (e.g. polyuria, multiple episodes, bulimia, and weight loss). Excessive insulin deficiency can lead to ketoacidosis. The development of ketoacidosis is the leading cause of death in diabetic men. The main objective of this study was to evaluate the antidiabetic activity of dental pulp cells in diabetic Wistar albino mice induced by streptozotocin (STZ), and to calculate the biochemical evaluation of diabetes drugs in the pharmaceutical industry in the normal and treatment groups.


Streptozotocin, Wistaralbino Rat, Insulin, Stemcell, Fibroblast

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